Bring a large pot of salted water to a boil and cook rotini according to package directions. Drain and set aside.
In a large skillet, heat olive oil over medium heat. Add ground beef and cook until browned. Drain excess grease.
Add Rotel tomatoes (undrained), Velveeta cubes, milk, garlic powder, and onion powder to the skillet.
Stir everything together and let simmer for 5-7 minutes, or until the cheese is fully melted and the sauce is smooth.
Add cooked pasta to the skillet and stir until evenly coated with the sauce.
Season with salt and pepper to taste. Garnish with fresh parsley if desired.
Serve hot and enjoy!