Preheat your smoker to 225°F using your preferred wood pellets.
Place frozen meatballs and Little Smokies in a disposable aluminum pan.
In a mixing bowl, whisk together BBQ sauce, brown sugar, Worcestershire sauce, garlic powder, and onion powder.
Pour the sauce mixture over the meatballs and smokies, stirring gently to coat.
Place the pan into the smoker uncovered and smoke for 2 to 2.5 hours, stirring occasionally.
Once the sauce thickens and meatballs are heated through, remove and serve hot.